These linking words and phrases are used to link contrasting ideas. The clauses can be reversed.
Despite / in spite of:
Used at the start of the sentence or at the start of the second clause.
“Despite” and “in spite of” are often used with “the fact that”.
After in spite of and despite, we use a noun, gerund (-ing form of a verb) or a pronoun.
Steven failed the exam, despite the amount of revision he did.
Despite the amount of revision he did, Steven failed the exam.
Mary enjoyed singing in the choir, in spite of her lack of talent.
In spite of her lack of talent, Mary enjoyed singing in the choir.
Though / although
Though Tom was one of the shortest in his class, he was the best basketball player.
Tom was the best basketball player in his class, though he was the shortest.
We often use “even” before “though” for added emphasis.